David Matson, MD, PhD

 

Professor of Pediatrics

Professor of Health Professions

Master of Public Health Program
Eastern Virginia Medical School

Division of Pediatric Infectious Diseases
Children's Hospital of The King's Daughters
601 Children's Lane
Norfolk, VA 23507
Phone: (757) 446-6120

Email:  MatsonDO@evms.edu

 

Background | Research Interests | Current Projects | Honors and Awards
Professional Affiliations | Selected Publications
Background
B.Sc. Chemistry (1976) Wheaton College, Wheaton, Ill.; Ph.D. Virology and Epidemiology (1981) Baylor College; Dissertation: Utilization of Herpes Simplex Virus Glycoproteins in a Radioimmunoasssay for Seroepidemiologic Studies of Cervical Neoplasia; Internship in Pediatrics (July 1983 - June 1984) Baylor College of Medicine; Residency in Pediatrics (July 1984 - June 1986) Baylor College of Medicine; Fellowships and Other Postdoctoral Training (July 1986 - June 1988) Medicine, Pediatric Infectious Diseases and Molecular Virology (Dr. Mary Estes).

Section head, Infectious Diseases, Center for Pediatric Research (1998 - present), Adjunction Associate Professor Biomedical Sciences (1994 - present) Old Dominion University. Member (2000 - present)Board of Trustees, Spafford Children's Center, Jerusalem; Volunteer (January 2002) Physicians for Peace, Nigeria
 
Research Interests
Current research activities focus on the diagnosis, epidemiology, immunology and prevention of viral gastroenteritis, particularly rotavirus, calicivirus and astrovirus illness. Active research grants involve collaborations with investigators in several countries and funding comes from national and international competitive awards. Most studies involve large, intensely monitored populations from which unique answers to research questions can be gleaned. For example, a recently completed multi-center study of all children hospitalized for diarrhea, vomiting and/or fever, with collection of a stool specimen and acute blood from the children within 24 hours of hospitalization, has led to a newer understanding of the diversity of clinical features of illnesses caused by the three viruses named above. An important aspect of this new study is that it may lead us to understand what has been called the "diagnostic gap" in severe gastroenteritis. This term refers to the cases in cross-sectional studies that cannot be ascribed to any known pathogen cause, no matter how intensely the symptomatic stool specimens are studied. Work from the multi-center study indicates fairly strongly that the cases in the diagnostic gap are infected with common pathogens, but excrete the pathogen at levels lower than can be detected with the best assays.

All of these studies are meant to advance the field of viral gastroenteritis, a syndrome known to cause about 800,000 deaths each year in children and recognized as one of the 10 major health issues worldwide on any such list (WHO, World Bank, and so forth).

I am happy to communicate with anyone about these interests.
 
Honors and Awards
  • Landa Fellow in Pediatric Infectious Diseases, 1986-1987.
  • Daland Fellow, American Philosophical Society, 1987-1989 (competitive award)
  • Department of Pediatrics Faculty Teaching Award, November-December, 2001
  • Dean's Faculty Research Award, Eastern Virginia Medical School, 2002
Professional Affiliations
  • Editorial Board: Journal of Virologic Methods
  • Rotavirus Vaccine and Intussusception Study Group (1999-present) through Centers for Disease Control and Prevention.
  • Member: Society of Pediatric Research (1994), Young Investigator Award Committee (2001, 2002)
  • American Academy of Pediatrics, Fellow
  • Pediatric Infectious Diseases Society, Fellow, Bylaws Committee (1994-1998) Research Affairs Committee (2000-2003)
  • Infectious Diseases Society of America, Member, Finance Committee (2001-2002)
  • American Society of Microbiology (1987-present)
  • American Society for Virology (1987-present)
Selected Publications
  1. Protection of breast-fed children against symptomatic rotavirus infection by human milk lactadherin. Lancet 1998;351:1150-4
  2. Dunham D*, Jiang X, Berke T, Smith AW, Matson DO. Genomic mapping of a calicivirus VPg. Arch Virol 1998;143:2421-30
  3. O'Ryan ML, Vial P, Mamani N, Jiang X, Estes MK, Ferrecio C, Lakkis HD, Matson DO. Assessment of independent risk factors for antibody acquisition to Norwalk and MX caliciviruses in Chilean individuals. Clin Infect Dis 1998;27:789-95
  4. Rinehart-Kim*, J, Zhong W-M, Jiang X, Smith AW, Matson DO. Complete nucleotide sequence and genomic organization of a primate calicivirus, Pan-1. Arch Virol 1999;144:199-208
  5. Mitchell DK, Matson DO, Cubitt WD, Jackson LJ, Willcocks MM, Pickering LK, Carter MJ. Prevalence of antibodies to astrovirus types 1 and 3 in children and adolescents in Norfolk, Virginia. Pedi Infect Dis J 1999;18:249-54
  6. Barlough JE, Matson DO, Skilling DE, Berke T, Berry ES, Brown RF, Smith AW. Isolation of reptilian calicivirus Crotalus type 1 from feral pinnipeds. J Wildlife Dis 1999;34:451-6
  7. Jiang X, Zhong W, Kaplan M, Pickering LK, Matson DO. Expression and characterization of Sapporo-like human calicivirus capsid proteins in baculovirus. J Virol Methods 1999;78:81-91
  8. Matson DO. Re-analysis of serologic data from the Australian study of human health risks of infection by rabbit hemorrhagic disease virus. Rabbit Control and RCD: Dilemmas and Implications. Royal Society of New Zealand, Wellington; Miscellaneous Series 55, 1999, pp. 62-6
  9. Mitchell DK, Matson DO, Jiang X, Berke T, Monroe SS, Carter MJ, Willcocks MM, Pickering LK. Molecular epidemiology of childhood astrovirus infection in childcare centers. J Infect Dis 1999;180:514-7
  10. Jiang X, Huang PW, Zhong WM, Farkas T, Cubitt DW, Matson DO. Design and evaluation of a primer pair that detects both Norwalk- and Sapporo-like caliciviruses by RT-PCR. J Virol Methods 1999;83:145-54
  11. O'Ryan ML, Salina AM, Mamani N, Matson DO, Jiang X, Vial PC. Detection of Norwalk and MX virus, two human caliciviruses, in stools of Chilean children. Rev Medica de Chile 1999;127:523-528.
  12. Jiang X, Wilton N, Zhong W, Farkas T, Huang PW, Barrett E, Guerrero M, Ruiz-Palacios G, Green KY, Estes MK, Pickering LK, Matson DO. Diagnosis of human caliciviruses by use of enzyme immune assays. J Infect Dis 2000;181:S349-59
  13. Espul C*, Cuello H, Martinez N, Ortiz M, O´Ryan ML, Matson DO. Genomic and antigenic variation among rotavirus strains circulating in a large city of Argentina. J Med Virol 2000;61:504-9
  14. Jiang X, Espul C, Zhong WM, Cuello H, Matson DO. Characterization of a novel human calicivirus that may be a naturally occurring recombinant. Arch Virol 1999;144:2377-87
  15. Velazquez R*, Matson DO, Guerrero ML, Shults J, Calva JJ, Morrow AL, Glass RI, Pickering LK, Ruiz-Palacios GM. Serum immunoglobulin A antibody as a marker of protection against natural rotavirus infection and disease. J Infect Dis 2000;182:1602-9
  16. Green KY, Ando T, Balayan MS, Clarke IN, Estes MK, Matson DO, Nakata S, Neill JD, Studdert MJ, Thiel H-J. Taxonomy of the caliciviruses. J Infect Dis 2000;181:S322-S330
  17. Farkas T*, Jiang X, Lourdes Guerrero M, Zhong W, Wilton N, Berke T, Matson DO, Pickering LK, Ruiz-Palacios G. Prevalence and genetic diversity of human caliciviruses in Mexican children. J Med Virol 2000;62:217-23
  18. Berke T, Matson DO. Reclassification of the Caliciviridae into distinct genera and exclusion of hepatitis E virus from the family on the basis of comparative phylogenetic analysis. Arch Virol 2000;145:1421-36
  19. Huang PW*, LaBorde D, Land VR, Matson DO, Smith AW, Jiang X. Concentration and detection of caliciviruses in water samples by reverse transcription-PCR. Appl Environ Microbiol 2000;66:4383-8
  20. O'Ryan ML, Mamani N, Gaggero A, Avendano LF, Prieto S, Pena A, Jiang X, Matson DO. Human caliciviruses are a significant pathogen of acute sporadic diarrhea in children of Santiago, Chile. J Infect Dis 2000;182:1519-22
  21. Taylor MB, Walter JE, Berke T, Cubitt WD, Mitchell DK, Matson DO. Characterization of a South African human astrovirus as type 8 by antigenic and genetic analysis. J Med Virol 2001;64:256-61
  22. Bok K*, Castagnaro N, Borsa A, Nates S, Espul C, Fay O, Fabri A, Grinstein S, Miceli I, Matson DO, Gomez JA. Surveillance for rotavirus in Argentina. J Med Virol 2001;65:190-8
  23. Walter JE, Mitchell DK, Lourdes Guerrero M, Berke T, Matson DO, Monroe SS, Pickering LK, Ruiz-Palacios G. Molecular epidemiology of human astrovirus among children from a periurban community of Mexico City. J Infect Dis 2001;183:681-6
  24. O'Ryan M, Pérez-Schael I, Mamani N, Peña A, Salinas B, González G, González F, Matson DO, Gómez J. Rotavirus-associated medical visits and hospitalizations in South America: A prospective study at three large sentinel hospitals. Pediatr Infect Dis J 2001;20:685-93
  25. Walter JE, Briggs J, Lourdes Guerrero M, Matson DO, Pickering LK, Ruiz-Palacios G, Berke T, Mitchell DK. Molecular characterization of a novel recombinant strain of human astrovirus associated with gastroenteritis in children. Archiv Virol 2001;146:2357-67
  26. Bok K*, Palacios G, Sijvarger K, Matson D, Gomez J. Emergence of G9 P[6] human rotaviruses in Argentina: phylogenetic relationships among G9 strains. J Clin Microbiol 2001;39:4020-5
  27. Staat MA, Azimi P, Berke T, Roberts N, Bernstein D, Ward RL, Pickering LK, Matson DO. Clinical presentation of rotavirus infection among hospitalized children. Pediatr Inf Dis J 2002;21:221-7
  28. Martinez N*, Espul C, Cuello H, Zhong WM, Jiang X, Matson DO. Sequence diversity of human caliciviruses recovered from children with diarrhea in Mendoza, Argentina, 1995 to 1998. J Med Virol, 2002;67:289-98
  29. Smith AW, Skilling DE, Matson DO, Kroeker AD, Stein DA, Berke T, Iverson PL. Detection of vesicular exanthem of swine-like calicivirus in tissues from a naturally infected spontaneously aborted bovine fetus. J Am Vet Med Assoc 2002;220:455-8.
  30. Jiang X, Zhong WM, Farkas T, Huang PW, Wilton N, Barrett E, Fulton D, Morrow R, Matson DO. Baculovirus expression and antigenic characterization of the capsid proteins of three Norwalk-like viruses. Arch Virol 2002; 147: 119-30.
  31. Bok K*, Matson, DO, Gomez JA. Genetic variation of capsid protein VP7 of genotype G4 human rotaviruses: simultaneous emergence and spread of different lineages in Argentina. J Clin Microbiol 2002;40:2016-22.
  32. Smith AW, Skilling DE, Houghton M, Matson DO. Transfusion-transmitted disease and evidence implicating a zoonotic calicivirus. Submitted.
  33. Reuter G*, Farkas T, Berke T, Jiang X, Szucs G, Matson DO. Molecular detection of Sapporo-like viruses in Hungary. Orv Hetil 2002;143:351-354.
  34. Reuter G*, Farkas T, Berke T, Jiang X, Szucs G, Matson DO. Molecular epidemiology of human calicivirus gastroenteritis outbreaks in Hungary, 1998 to 2000. J Med Virol 2002; in press.
  35. Farkas T, Berke T, Reuter G, Szucs G, Matson DO, Jiang X. Molecular detection and sequence analysis of human caliciviruses from acute gastroenteritis outbreaks in Hungary. J Med Virol 2002;67:567-573.

* Indicates fellow or student working under my supervision.

Other Full Papers (Published without review by peer group)

  1. Matson DO. Rotavirus vaccines. Report on Pediatric Infectious Diseases 1997;7(4)
  2. Rennels MB, Black RE, Chartrand SA, Matson DO, Vesikari T. Advances in the prevention of rotavirus associated pediatric gastroentertis. Monograph. Dannemiller Memorial Educational Foundation. April, 1997, 19 pages
  3. Matson DO. Current status of rotavirus immunization. Clinical Updates in Pediatric Infectious Disease1997;2(4):1-4
  4. Matson DO. 2000. Rotavirus infections. In Stockman JA and Lohr JA, eds. Essence of Office Pediatrics. New York: WB Saunders, p. 348.
  5. Smith AW, Matson DO, Stein DA, Skilling DE, Kroeker AD, Berke T, Iversen PI. Antisense treatment of Caliciviridae: an emerging disease agent of animals and humans. Curr Opin in Mol Therapeutics 2002;4:177-84.

Books

  1. Matson DO. http://rotavirus.com. A webpage distributed on the Internet. Contains 70 single-spaced pages of original text in a total of 494 pages, June, 1996. Second edition: June, 1997. Third edition: May, 1999. Discontinued March, 2001
  2. Jiang X, Laborde D, Land VR, Matson DO. Detection of caliciviruses in water samples. Technical report published by American Water Works Association Research Foundation and the American Water Works Association, Denver, Colorado. 2001, 122 pp.
  3. Matson DO (Participant). Gastroenteritis Viruses. Novartis Symposium 238. D Chadwick, JA Goode, Editors. Chichester, England: John Wiley & Sons, 2001, 323 pages.

Book Chapters

  1. Matson DO. 1997. Caliciviruses and calici-like viruses, 1997 Report of the Committee on Infectious Diseases, the "Red Book", American Academy of Pediatrics, pp. 159-60
  2. Jiang X, Matson DO. 1997. Detection of human caliciviruses and astroviruses in stools by RT-PCR. In Diagnostic Virology Protocols. Volume 12 of Methods in Molecular Medicine. JR Stephenson, A Warnes, eds. Totowa, New Jersey:Humana Press, pp. 19-27
  3. Matson DO. 1997. Calicivirus infections. In Textbook of Pediatric Infectious Disease, 4th Edition. RD Feigin, JD Cherry, eds. Philadelphia: WB Saunders, pp. 1882-1892
  4. Mitchell DK, Jiang X, Matson DO. 1999. Gastroenteritis. In Essentials of Diagnostic Virology, G Storch, ed. New York: Churchill Livingstone, pp. 79-92
  5. Matson DO, Pickering LK, Mitchell DK. 1999. Viral gastroenteritis. In Oski's Pediatrics. Philadelphia: Lippencott Williams & Wilkins, pp. 1147-51
  6. Matson DO. 2000. Rotavirus. In Essence of Office Pediatrics, JA Stockman, JA Lohr, eds. Philadelphia: WB Saunders, p. 348
  7. Matson DO, O'Ryan ML, Jiang X, Mitchell DK. 2000. Rotavirus, enteric adenoviruses, caliciviruses, astroviruses, and other viruses causing gastroenteritis. In Clinical Virology Manual, 3nd Edition. S Spector, RL Hodinka, SA Young, Editors. Washington DC; ASM Press, pp. 270-294
  8. Green KY, Ando T, Balayan MS, Clarke IN, Estes MK, Matson DO, Nakata S, Neill JD, Studdert MJ, Theil H-J. 2000. Caliciviridae. In van Regenmortel MHV, Fauquet CM, Bishop DHL, Carstens EB, Estes MK, Lemon SM, Maniloff J, Mayo MA, McGeoch DJ, Pringle CR, Wickner RB. Virus Taxonomy: Classification and Nomenclature of Viruses. Seventh Report of the International Committee on Taxonomy of Viruses. San Diego: Academic Press, pp. 725-35
  9. Green KY, Berke T, Matson DO. 2000. "Hepatis E-like viruses" In van Regenmortel MHV, Fauquet CM, Bishop DHL, Carstens EB, Estes MK, Lemon SM, Maniloff J, Mayo MA, McGeoch DJ, Pringle CR, Wickner RB. Virus Taxonomy: Classification and Nomenclature of Viruses. Seventh Report of the International Committee on Taxonomy of Viruses. San Diego: Academic Press, pp. 735-9
  10. Matson DO. 2002. Rotavirus. In Current Pediatric Therapy 17. FD Burg, JR Ingelfinger, A Gershon, RA Polin, eds. Philadelphia: WB Saunders, pp. 141-142.
  11. Matson DO. 2002. Viral Gastroenteritis. In Principles and Practice of Pediatric Infectious Diseases. 2nd Edition. SS Long, CG Prober, LK Pickering, eds. New York: Churchill Livingstone, in press
  12. Matson DO. 2002. Rotaviruses. In Principles and Practice of Pediatric Infectious Diseases. 2nd Edition. SS Long, CG Prober, LK Pickering, eds. New York: Churchill Livingstone, in press
  13. Matson DO. 2002. Caliciviruses. In Principles and Practice of Pediatric Infectious Diseases. 2nd Edition. SS Long, CG Prober, LK Pickering, eds. New York: Churchill Livingstone, in press
  14. Matson DO. 2002. Astroviruses. In Principles and Practice of Pediatric Infectious Diseases. 2nd Edition. SS Long, CG Prober, LK Pickering, eds. New York: Churchill Livingstone, in press
  15. Matson DO. 2002. Calicivirus Genome Recombination. In Viral Gastroenteritis: Perspectives in Medical Virology. U Desselberger, J Gray, eds. In press.
  16. Matson DO. 2002. Caliciviruses and hepatitis E virus. In Textbook of Pediatric Infectious Disease, 5th Edition. RD Feigin, JD Cherry, eds. Philadelphia: WB Saunders, in press

Other Publications

  1. "Jenny Anderson Show", National Radio of New Zealand, on the rabbit calicivirus release, two hours, August 26, 1997
  2. O'Ryan ML, Matson DO. Letter to the editors. A quadrivalent rotavirus vaccine. New Engl J Med 1998,338:620-1
  3. Smith AW, Cherry NJ, Matson DO. Letter to the editors. A brief update on rabbit hemorrhagic disease virus. Emerging Infect Dis 1998;4:345-6
  4. Dennehy PH, Matson DO, Rennels MB. Prevention of rotavirus gastroenteritis: Recommendations of an advisory committee on the prevention of rotavirus gastroenteritis. San Antonio, Texas: Dannemiller Memorial Educational Foundation, September, 1998, Slide-Lecture Program, 54 slides.
  5. Matson DO. Book review. Rotaviruses: Methods and Protocols. Desselberger U and Gray U, eds. Humana Press, New Jersey, in Antiviral Research 2000;47:53-6
  6. Matson DO. A different perspective on a rotavirus vaccine. Vaccine. 2001;19:2763.

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Copyright © 2004 Eastern Virginia Medical School Department of Pediatrics
Last modified: 08/19/2008